Lymphocyte Function-Associated Antigen-1

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

Also Known As:

LFA-1; Integrin alphaLbeta2; Antigen-1, Lymphocyte Function-Associated; Lymphocyte Function Associated Antigen 1; alphaLbeta2, Integrin; Leukocyte Function Associated Antigen-1

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Lymphocyte Function-Associated Antigen-1: 845
        CD11 Antigens: 1
        Lymphocyte Function-Associated Antigen-1: 845
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Lymphocyte Function-Associated Antigen-1: 845
        CD11 Antigens: 1
        Lymphocyte Function-Associated Antigen-1: 845
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Lymphocyte Function-Associated Antigen-1: 845
        CD11 Antigens: 1
        Lymphocyte Function-Associated Antigen-1: 845
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Leukocyte-Adhesion Receptors: 19
        Lymphocyte Function-Associated Antigen-1: 845
        Lymphocyte Homing Receptors: 25
        Lymphocyte Function-Associated Antigen-1: 845
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Cell Adhesion Molecules: 4858
      - Lymphocyte Homing Receptors: 25
        Lymphocyte Function-Associated Antigen-1: 845
      - CD11 Antigens: 1
        Lymphocyte Function-Associated Antigen-1: 845

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Eider San Sebastián Research Topics

Disease

Drug/Important Bio-Agent (IBA)